Stage IIB Ovarian Cancer Treatment

Stage IIB Ovarian Cancer Treatment

• Develop the management plan (pharmacological and nonpharmacological).
• Discuss the appropriate diagnostic testing for the patient
• Discuss differential diagnoses with ICD 10 numbers for each.
• Base on the International Federation of Gynecology and Obstetrics (FIGO) give treatment examples for a patient with a Stage IIB Ovarian Cancer.

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APA

Stage IIB Ovarian Cancer Treatment

1. Management Plan (Pharmacological and Nonpharmacological)

Pharmacological Management

1. Chemotherapy

   • Neoadjuvant chemotherapy (before surgery) or adjuvant chemotherapy (after surgery)
   • First-line agents:
     • Carboplatin (AUC 5–6) + Paclitaxel (175 mg/m² IV every 3 weeks)
     • Alternative: Cisplatin-based regimens if carboplatin is contraindicated

2. Targeted Therapy

   • Bevacizumab (Avastin): VEGF inhibitor used in combination with chemotherapy for advanced ovarian cancer
   • PARP inhibitors (for BRCA-mutated cases): Olaparib, Niraparib, or Rucaparib

3. Hormonal Therapy (Less Common)

   • Tamoxifen or Letrozole for hormone-sensitive ovarian cancers

4. Pain and Symptom Management

   • Opioid Analgesics: Morphine, Fentanyl patches for pain control
   • Antiemetics: Ondansetron for chemotherapy-induced nausea and vomiting
   • Bone Marrow Support: Filgrastim for neutropenia prevention

Nonpharmacological Management. Stage IIB Ovarian Cancer Treatment

1. Surgical Intervention (Cytoreductive Surgery/Debulking Surgery)

   • Total abdominal hysterectomy with bilateral salpingo-oophorectomy
   • Pelvic and para-aortic lymph node dissection
   • Omentectomy if metastasis is present

2. Nutritional Support

   • High-protein diet to maintain strength during treatment
   • Nutritional counseling to manage chemotherapy side effects

3. Psychosocial and Palliative Care

   • Support groups and counseling for emotional well-being
   • Palliative care referral for symptom relief and quality of life improvement

4. Physical Therapy and Rehabilitation

   • Exercise programs to improve strength and fatigue management

2. Diagnostic Testing

1. Imaging Studies

   • Pelvic and Abdominal CT Scan or MRI: To evaluate tumor spread
   • PET Scan: For metastasis assessment

2. Laboratory Tests

   • CA-125 tumor marker: Elevated levels suggest ovarian malignancy
   • Complete Blood Count (CBC): To monitor for anemia and leukopenia
   • Liver and Kidney Function Tests: To assess chemotherapy tolerance

3. Histopathological Examination

   • Biopsy from the ovarian mass to confirm malignancy

4. Genetic Testing

   • BRCA1 and BRCA2 mutation testing: Helps guide